HORDB

ID: hor001907
Uniprot ID: Q60549
Protein name: Somatoliberin
Gene name: GHRH
Organism: Mesocricetus auratus (Golden hamster)
Family: Glucagon family
Source: animal
Expression: hypothalamus
Disease: NA
Comments: NA
Taxonomy: Mesocricetus (genus), Cricetinae (subfamily), Cricetidae (family), Muroidea, Myomorpha (suborder), Rodentia (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005102 signaling receptor binding; GO:0005179 hormone activity; GO:0005184 neuropeptide hormone activity
GO BP: GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway; GO:0032879 regulation of localization
GO CC: GO:0005576 extracellular region

Sequence: YADAIFTSSYRKVLGQLSARKLLQDIMSRQQGERNQEQGPRVRL
Length: 44
Propeptide: MPLWVFFVILTLTNGSHCSPSPSLPFRIRRYADAIFTSSYRKVLGQLSARKLLQDIMSRQQGERNQEQGPRVRLGRQVDSMWADHRQMSLESLLAALLQKHSRDSQG
Signal peptide: MPLWVFFVILTLTNGSHCS
Modification: T44 Leucine amide
Glycosylation: NA
Mutagenesis: NA

Function: Acts on the adenohypophyse to stimulate the secretion of growth hormone
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P30990-F1.pdb

hor001907_AF2.pdb

hor001907_ESM.pdb

Mass:	587598	Formula:	C220H365N71O67S
Absent amino acids:	CHW	Common amino acids:	QR
pI:	10.91	Basic residues:	8
Polar residues:	11	Hydrophobic residues:	13
Hydrophobicity:	-82.05	Boman Index:	-13191
Half-Life:	2.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	2 min	Aliphatic Index	82.05
Instability Index:	5122.27	Extinction Coefficient cystines:	2980
Absorbance 280nm:	69.3